Within FLOSS, I do have preferences (e.g. Python over Perl), but this post is about my preferences over proprietary alternatives.
3D content creation: Blender should be mainstream... used in blockbusters
desktop: GNOME should replace Mac OS X as THE desktop experience, and then steal the market
image manipulation: GIMP should acquire feature-parity with Photoshop, and then steal the market
DBMS: PostgreSQL should acquire feature-parity with Oracle, and then steal the market
Operating system: Debian should be THE reference platform for various user types (large corporations, audio/video professionals, software developers, gamers, etc.), taking the market away from OS X and Windows