David Beazley's PyCon 2012 key note talk is among the best I've seen in the field of software development. It's not even the content (the complexity and hackability of PyPy), but rather the presentation itself. The guy must have put a lot of effort in his slides, and what's better is that he was also doing live demonstrations. From those, you could gather that this isn't a mere mortal. He's brilliant (and humorous). And I've never even heard of him before, but he appears to be some sort of legend in the Python community.